Clinical Scenario: Up to 40% of individuals with ankle sprain develop chronic ankle instability (CAI). CAI results in mechanical and functional limitations, such as decreased ankle range of motion. Studies suggest that using therapeutic exercise with joint mobilization may be more effective in increasing ankle range of motion than therapeutic exercise alone. However, it remains unclear if there is a synergistic effect of therapeutic exercises when used with joint mobilizations. Clinical Question: In patients with chronic ankle instability, does therapeutic exercise with joint mobilization improve ankle range of motion more effectively than therapeutic exercise alone? Summary of Key Findings: We searched literature using various electronic databases. We included 3 randomized control trials for CAT. All three studies assessed ankle range of motion using a goniometer. All 3 studies have consistently shown that joint mobilization coupled with therapeutic exercise increases range of motion quicker than with therapeutic exercise alone. One study did recommend that more research needs to be done based on different joint mobilizations that can be used. Clinical Bottom Line: The use of joint mobilization with therapeutic exercise is effective for increasing range of motion in patients with CAI. Strength of Recommendation: There is grade A evidence that shows joint mobilization with therapeutic exercise improves range of motion in patients with CAI.